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According to Marie Claire, the opioid epidemic is now the worst drug epidemic in history, with nearly 100 Americans dying every day from an opioid overdose.

In fact more people are now dying from opioids—both heroin and prescription painkillers like OxyContin, Vicodin, Fentanyl, and Percocet—than from car accidents or gun homicides.

Despite the alarming numbers, it can sometimes be hard to envision the real, human face of this heartbreaking problem. Which is why HBO Documentary Films decided to follow along as four families, whose lives have been decimated by opioids, try to climb out of the depths of addiction and despair.

The resulting film, “Warning: This Drug May Kill You,” on HBO, is an unflinching look at the reality of the epidemic and the disease of addiction. It’s terrifying and often hard to watch, but you should anyway.

Director Perri Peltz details how we got here, what women especially need to know, and what can be done to curb this devastating epidemic.

Read the full interview here.